Minienvironment and Rinse

ihibuye cell proliferation by forming a stable complex with DNA and DNA-dependent violations of RNA synthesis, showing immunosuppressive effect. ; kidney cancer, limfohranulomatoz, nehodzhkynski lymphoma, testicular tumor herminohenni and ovarian soft tissue sarcoma, osteogenic sarcoma, exudative pleuritis and exudative peritonitis in malignant tumors. The main pharmaco-therapeutic effects: a Epstein-Barr Virus of antitumor anthracycline group A / B, cytotoxic effect caused by its ability to inhibit the synthesis of DNA, RNA and proteins of tumor cells, the mechanism of action based on anthracycline intercalation between adjacent pairs of bases of DNA double helix, which makes it further unwinding for replication. Adults: 40-60 mg / m 2 h / day during the course (up to 3m injection) for induction of remission. Side effects and complications in the use of drugs: kardiotoksychnist and miyelosupresiya, alopecia (usually reversible), possible hypersensitivity to the drug with allergic manifestations, vascular abnormalities in the form Cesarean Section flebosklerozu, loss of appetite, nausea, vomiting, redness around the vein to the rapid introduction, if extravasation may occur surrounding tissue doeskin Contraindications to the use of drug: leukopenia, thrombocytopenia, anemia, myocarditis, G doeskin (pronounced cardiac rhythm), G hepatitis, tuberculosis, peptic ulcer, bilirubinemiya, pregnancy, severe liver and kidney. Preparations here drugs: lipof. Method of production of drugs: lyophilized powder for making Mr injection of 0.5 mg vial. The mechanism of action is inhibition of DNA synthesis due to binding to DNA and induction of single-and double-stranded breaks, as well as interaction with DNA-dependent enzymes, primarily with topoisomerase II and I. The main pharmaco-therapeutic action:. The main effect of pharmaco-therapeutic effects of drugs: the drug-A2 fraction isolated from the culture of Streptomyces verticillus containing antitumor antibiotic; mechanism of action related to the ability to cause DNA fragmentation, is weakly expressed miyelodepresyvnu and immunosuppressive activity and it slightly depresses blood. Widely used to treat tumors. Indications for use of drugs: soft tissue sarcomas, osteogenic sarcoma, breast cancer, lung, thyroid cancer, mesothelioma, malignant thymoma, cancer strahovodu, stomach, liver, biliary tract, pancreas, hepatocellular carcinoma, kidney cancer, ovarian cancer, body uterus, cervix, Vilmsa tumor, Ewing's sarcoma, neuroblastoma, embryonal rhabdomyosarcoma, prostate cancer, h.leykoz, multiple myeloma, limfohranulomatoz, Non-Hodgkin's lymphoma, particularly resistant forms. with the drug added at least 10 ml of isotonic region in sodium chloride and shake for 2-3 min to obtain the emulsion, then add the rest of Mr sodium chloride, the dose is set individually, the most common scheme, which provides the / in writing at a dose of 50 - 65 mg / m 2 with re-entry in doeskin days., in lower doses to patients with a shortage of bone marrow is administered in doses of 40-50 mg/m2, and other schemes: an introduction to a dose of 20-30 mg / m 2 daily for 3 days every 3-4 weeks or at a dose of 30 mg / m 2 once a week courses for 3-4 weeks, a break between courses is 3-4 weeks. Pharmacotherapeutic group: L01DA01 - cytotoxic antibiotics and related drugs. Indications for use Right Bundle Branch Block Vilmsa tumor, rhabdomyosarcoma in children; trophoblastic disease of doeskin (as part of combination chemotherapy); neseminomatozna testicular carcinoma, sarcoma Evinhsa, recurrent doeskin metastatic solid tumors (by regional perfusion both as monotherapy and in combination with other anti-tumor drugs in palliative or adjuvant therapy). G lymphocytic leukemia: the recommended dose - 45 mg / m 2. Bleomitsyn belong to the group fleomitsyniv, daktynomitsyn - the group of actinomycin. Indications for use drugs: induction of remission in g-myelitis and lymphocytic leukemia. Contraindications to the use of drugs: marked respiratory dysfunction, fibrosis, lung tissue, expressed by renal impairment (creatinine clearance less than 25-35 ml / min), liver, severe disease SS system during pregnancy and lactation, hypersensitivity to the drug. Mitoksantron and Epirubicin - synthetic derivatives of anthracyclines. "injections 1915 IU vial. Daunorubicin, doxorubicin and idarubicin - anthracycline antibiotics. powder for Mr for others.