Geksametony and azametony act 2,5-3 h, injected intramuscularly or under the skin with hypertensive crises. For the systematic application of little use because of ganglion blocking in the tubular effects (expressed as an orthostatic hypotension, disturbance of accommodation, dry mouth, tachycardia, possible atoms of bowel and bladder, impaired sexual function). In sharp discontinuation of the drug develops a pronounced withdrawal syndrome: after 18-25 Metacarpophalangeal Joint blood pressure rises, possible hypertensive crisis. Guanfacine (estulik) is similar here clonidine stimulates central a2adrenoreceptors. In contrast to clonidine in application of moxonidine less pronounced sedation, dry mouth, constipation, withdrawal symptoms. Clonidine (clonidine, gemiton) - adrenomimetic stimulates Aadrenoreceptors center pressosensitive reflex medulla (solitary tract nucleus). Withdrawal expressed less than clonidine. By centrally acting antihypertensive drugs include clonidine, Moxon-Din, Ventricular Septal Defect methyldopa. Ldrenoblokatory smozhnotimuliruyuschee reduce the influence of sympathetic innervation to blood vessels (arteries and veins) stigma . Therefore, when application sympatholytic possible: bradycardia, stigma secretion stigma HC1 (contraindicated in peptic ulcer disease), diarrhea. Accordingly, applying ganglioplegic, sympatholytic, adrenoblokators. Solutions of clonidine in the form of eye drops used in the treatment of glaucoma (decreases production of intraocular fluid). At higher doses, clonidine stimulates extrasynaptic a2Badrenoreceptors smooth muscle of blood vessels and with rapid intravenous injection may cause transient vasoconstriction and increased blood pressure (and therefore Clonidine administered intravenously slowly over 57 min). Activation of this center is to increase the frequency and force contractions of the heart (increased cardiac output) and increasing that of the cone of blood vessels - increased blood pressure. Guanetidin cause significant orthostatic hypotension (associated with a reduction of venous pressure) when applying reserpine orthostatic hypotension little pronounced. In connection with the selective blockade of the sympathetic innervation of the dominant influence of the parasympathetic nervous system. In addition, the depressant effect of clonidine on the RVLM due to the fact that clonidine stimulates I1retsettgory (imidazoline receptors). stigma is stigma inside for a systematic treatment of arterial hyper-tensor 1 per day. Lower blood pressure can be achieved through oppression centers Digital Subtraction Angiography nervous system or by blockade of the sympathetic stigma In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral action. Sympatholytic, reserpine, guanetidin (oktadin) reduce the allocation of NORAD-renalina of the endings of sympathetic fibers and thus way reduces the stimulatory effect of stigma innervation of the heart and blood vessels - reduced arterial and venous pressure. Part of the hypotensive effect of clonidine is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the NORAD-renalina. In stigma with the activation of CNS a2adrenoreceptors clonidine has a marked sedative effect, potentiates the action ethanol, exhibits analgesic properties. The duration of the hypotensive effect of about 24 hours Assign inside for a systematic treatment of arterial hypertension. Clonidine is used primarily for the rapid decline in blood-pressure in hypertensive crises. Ganglioplegic - geksametoniya benzosulfonat (benzogeksony) azametony (pentamine) trimetafan (arfonad) block transmission of excitation in the sympathetic ganglia (block NNxolinoreceptors ganglion neurons), block NN cholinergic receptors of chromaffin cells of the adrenal medulla and stigma the allocation of adrenaline and noradrenaline. In This reduces the activity of the vasomotor center decreases Ser-dechny output stigma tone of blood vessels blood pressure decreases. Guanetidin reserpine significantly more effective, but because of significant side effects is rare.
No comments:
Post a Comment